| Credit |
6 points |
| Availability |
offshore teaching period |
| Outcomes |
Students are able to recall and integrate key knowledge and concepts relating to (1) drug bioavailability; (2) routes of drug administration and drug absorption pathways; (3) peroral, dermatological and mucosal therapeutic products and their formulation; (4) excipients in therapeutic product formulation; (5) powder characterisation; (6) preservation of therapeutic products; (7) packaging materials for therapeutic products; and (8) pharmacopoeial standards for therapeutic products.
Students also acquire skills in the art and science of preparing a range of therapeutic dosage forms of the correct strength and stability. |
| Content |
This unit encompasses a diverse range of topics, from fundamental physiochemical principles that underpin the formulation of acceptable therapeutic products to the manufacture and evaluation of these products according to regulatory standards. It covers the formulation of major non-sterile pharmaceutical dosage forms, including powders, tablets, capsules, solutions, disperse systems, semi-solids, suppositories and specialised dosage forms, such as transdermal and timed-release medications. The properties and function of excipients, including preservatives, essential to the formulation of therapeutic agents are considered. The unit also evaluates the interrelationship between therapeutic product formulation and clinical outcome. An understanding of these principles allows the student to develop aesthetically pleasing products to deliver drugs in a safe, efficient, reproducible and convenient manner in patients.
The manufacture of some of these therapeutic products is undertaken in the laboratory with emphasis on both the science and art of formulation. |
| Assessment |
This comprises practical reports (15 per cent), continuous assessment (15 per cent) and a final examination (70 per cent).
Supplementary assessment is not available in this unit except in the case of a bachelor's pass degree student who has obtained a mark of 45 to 49 and is currently enrolled in this unit, and it is the only remaining unit that the student must pass in order to complete their course. |
| Unit Co-ordinator(s) |
Professor Lee Yong Lim |
| Location |
Singapore (PSB Campus) |
| Mode |
on-campus |
| Unit Rules |
| Prerequisites: CHEM2221 Biological and Medicinal Chemistry, PHYL2255 Physiology of Human Body Systems, CHEM3312 Chemistry of Drug Design and Discovery |
Contact hours—lectures: 30 hrs; tutorials: 5 hrs; practicals: 18 hrs
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| Texts | Allen, L. V. et al. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, 8th edn: Lippincott Williams and Wilkins 2005 Aulton, M. Pharmaceutics: The Design and Manufacture of Medicines, 3rd edn: Churchill Livingstone 2007
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- The availability of units in Semester 1, 2, etc. was correct at the time of going to press but may be subject to change.
- Assistance with study skills, including English language skills, is available free of charge from Student Services for all enrolled students (see http://www.studentservices.uwa.edu.au/ss/learning). Student Services location: Second Floor, South Wing, Guild Village; telephone: 6488 2423.
- Books and other materials wherever listed may be subject to change. Book lists relating to 'Preliminary Reading', 'Recommended Reading' and 'Textbooks' are, in most cases, available at the University Co-operative Bookshop (from early January) and appropriate administrative offices for students to consult. For first-year units the Bookshop will endeavour to make available photocopies of book lists for individual units. Books marked with an asterisk (*) are available in paperback.
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